Effervescent alkali compound and process of manufacturing and preparing the same



Patented Feb. 17,1925.

umrsn s'ra'rss FREDERICK W. HEYL,

. Q I OF KALA'MAZOO, MICHIGAN, ASSIGNOR TO THE UPJ'OHN COM- PANY, OFKALAMAZOO, MICHIGAN.

nrrnnvnscnn'r ALKALI comrounn AND rnocnss or MANUFACTURING AND ran-PARING THE SAME.

- No Drawing.

turing and Preparing the Same, of which the following is aspecification.

This invention relates to effervescent alkali compounds and the processof manufacturing and preparing the same.

Under ordinary circumstances it is known I that lime salts in solutionsare precipitated by an addition of sodium bicarbonate so that where thetwo bases have been admixed such medication has been carried out by theuse of two or more individual pharmaceutical preparations. Most limesalts have a. disagreeable taste so that medication has in the past beencarried out disadvantageously with lime saltsin compressed tablets.

- -Where it has been attempted to meet therequirement to administer limesalts in so lutions, the use of naturally occurring alkaline waters hasbeen found deficient. The objects of this invention are, first, toprovide an improved effervescent salt compound capable of forming asolution embracing soluble lime to be administered simultaneously withmassive doses of sodium bicarbonate.

Second to provide an' improved process of manuiacturing such a salt.

-Third, to provide an improved efiervescent salt capable of carryingbasic soluble salts effectively in solution without precipitation.

In the efiervescent compound of my invention therelation of the dose ofsodiumbicarbonate to the lime salt (e. g. calcium lactate) may be variedwithin rather-wide limits, but ispra'ctical in the ratio of 5 to 1respectively. ,The solution of the salt when dissolved and allowed toefl'ervesce is characterized by its palatability. In this eflt'ervescentalkaline compound'use is made of the solvent influence of freshlysurcharged carbonic water to hold the lime insolution. This can beaccomplished only by limiting the relationship of the lime saltto thesodium bicarbonate within well defined ratios. Also, the preparationmust be so made that a vigorous generation of carbonic dioxide without-tate 5 parts,

Application filed February 2, 1923. Serial No. 616,599.

ensues when the effervescent powder is dissolved 1n water.

This involves a special method of ma nipulation to preventthe formationof insoluble calcium or other alkaline earth carbonate in the process ofmanufacture. In the following example I give an illustrative method forcarrying out the invention. This may of course bevaried withinlimitations departing from the fundamental spirit of the invention. I Toproduce the granular effervescent alkaline compound containing sodiumbicarbonate and calcium lactate, I take by weight dry citric acid 25parts, dry tartaric acid 15 parts, dry sodium bicarbonate 67.8 parts,potassium bicarbonate 1 part, calcium lacalong with small additionalparts of sodium chloride, magnesium sulphate or lactate, and sodiumphosphate. The quantities of magnesia, phosphoric acid, chlorine, potashand lime may be calculated to approximate the relative proportions ofthese elements in the blodd' or serum. Thus the alkalies administeredare balanced and on a rational basis related to the basal requirementsof the body.

The alkaline ingredients are mixed and the organic acids are added. Themixture is rapidly moistened with a suitable relatively unreactiveorganic medium, e. g. 95% alcohol. It is immediately conveyed to a"acuum drier which has been previously heated to 50 degrees centigrade.After the mass has assumed a proper consistency it is broken granularcondition and returned to the vacuum and desiccated, The loss in carbondioxide is limited and with proper manipulation amounts to less than 15%of the calculated amount. Unless this is effectively controlled byprompt manipulation, much larger losses of carbon dioxide ensue withconsequent untoward efi'ectupon the solubility of the lime salt.

The dried efiervescent granules are immediately packaged in. sealed, airtight conof the lime salts I T and all others, giving aperfectly clearIhave'indicated variations of proportions possible, and there are alsovariations in the process which are permissible. I desire to claim thecompound broadly and specifi-- cally, as well as the process ofmanufacturmg, and also desire to claim the process of.

surcharging .with carbonic acid gas to insure the solution of the lime.

aving thus described my invention,

what I claim as new and desire to secure by Letters Patent is:

1. An effervescent compound comprisinga mixture of sodium bicarbonateand calcium lactate in the proportion of 21 to 4 additional sodiumbicarbonate in the proportion of 46.8 parts to 15 parts of tartaric acidand 25 parts of citric acid, thevproportions being such that the sodiumbicarbonate 3. The process of preparing an eflervescent salt consistinof admixing sodium bicarbonate and ca cium lactate in the proportions ofat least 5 to 1, with a mixture of tartaric acid and citric acid, withsodium bicarbonate sufiicient to react therewith, moistenin the samewith an unreactive organic me ium such as 95% alcohol, drying the samein vacuum at 50 degrees centigrade, reducing the mass to granularcondition, completely desiccating the same and enclosin in hermeticallysealed packages,

as specified.

4. The process ofpreparing an efl'ervescent salt consisting of admixingsodium bicarbonate and calcium lactate in the proportening the same withan unreactive organic medium, drying the same in vacuum at 50 degreescenti rade, reducing the 'mass to granular condition, completelydesiccating the same, and enclosing in hermetically sealed packages, .asspeclfied.

In witness whereof, I have hereunto set my hand and seal.

FREDERICK W. HEYL. 1,. 5.

